Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A is one of four major analogs of the enniatin complex and has previously not been available for investigation
Cyclohexadepsipeptide mycotoxin. One of four major analogs in the enniatin complex. Commonly found food contaminant in cereals and their products.
Ionophore antibiotic. Incorporation into the cell membrane forms dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling.
Anticancer compound. Triggers apoptosis in several cancer cell lines. Leads to loss of mitochondrial membrane potential and cell cycle arrest.
Moderate inhibitor of ACAT (acylcoenzyme A:cholesterolacyl transferase).
Shown to have a variety of other biological activities such as antifungal, anthelmintic, insecticidal, immunomodulatory and phytotoxic activity.
Solubility:Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability:Lyophilized powder may be stored at 4°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Protect from light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
