Cyclopiazonic acid is a tremorigenic indole produced by several species of the genera Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the induction of release of intracellular stored Ca2+ without increasing IP3.
Source:Cylcopiazonic acid from Penicillium griseofulvum.
Molecular Weight:~336.4
Solubility:Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
