85-1769-45　Rac1 Inhibitor (NSC23766) 25mg　CAS No:1177865-17-6　029597

特徴

• A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50~50uM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50-100uM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50=50 mM and 64mM, respectively).
• Synonyms:N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4- pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
• Molecular Formula:C₂₄H₃₈Cl₃N₇
• Molecular Weight:530.96
• Appearance:Supplied as a lyophilized powder.
• Purity:~99% (HPLC)
• Solubility:Soluble to 100mM in water and to 100mM in DMSO.
• TLC Conditions:Rf = 0.39 (Pyridine: Acetic acid: Water: Butanol [3:8:11:22])
• Method for Determining Identity:Proton NMR Spectroscopic and Mass Spectrometric Analysis
• Elemental Analysis:Calculated: %C: 51.66, %H: 7.41, %N: 17.57
• Storage and Stability:Stored at RT. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.