85-1769-28　Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) 5mg　CAS No:612847-09-3　029414

特徴

• A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
• Primary Target:Akt1, Akt2, Akt3
• Solubility:DMSO (5mg/ml)
• Molecular Weight:~551.6
• Appearance:Supplied as a yellow solid.
• Purity:≥95% (HPLC)
• Storage and Stability:Store at 4°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.