85-1769-21　Nalidixic Acid 25g　CAS No:389-08-2　N0015-76

特徴

• Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1] Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth.
• Synonyms:1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicAcid; 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; Betaxina; Cybis; Dixiben; Eucistin; NegGram; Nelidix; Win 18320; Wintomylon
• Molecular Formula:C12H12N2O3
• Molecular Weight:232.24
• Purity (1H-NMR):≥98%
• Appearance:White to yellow powder
• FT-IR:Conforms to reference
• Melting Point:230-231°C (lit)
• Storage and Stability:
Store at RT. Stable for 12 months after receipt.