85-1717-76　Vemurafenib, Free Base (PLX4032) 100mg　022761

特徴

• Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
• Appearance:Cyrstalline solid
• Purity:≥99% (HPLC)≥99% (TLC)
• Melting Point:269-270.5°C
• Method for Determining Identity:Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
• Solubility:Soluble in DMSO at 100mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility
• Storage:Store at or below -20ºC.
• Note:As of September 2011 the current correct CAS number for vemurafenib, also known as PLX4032, is given above. Chemical Abstracts Service recently canceled another CAS number, 1029872-54-5, that had previously been used for vemurafenib under its older name, PLX4032. However, this canceled number remains in wide use and receives the vast majority of hits on Google.