85-1707-28　［受注停止］N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt 1mg　CAS No:Free Acid: 17388-80-6　021096

特徴

• A metabolite of Purine. Purine metabolism by adenylosuccinase deficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
• Synonyms:N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic Acid Disodium Salt; SAICAR Disodium Salt
• Molecular Formula:C13H16N4Na2O9
• Molecular Weight:418.27
• Purity (HPLC):≥95%
• Appearance:White to yellow solid
• Solubility:Water (Slightly)
• Melting Point:>230ºC (dec) (lit)
• Method for Determining Identity:Proton NMR Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:C18; Acetonitrile: Methanol = 9:1; Visualized with UV and KMnO4; SIngle spot, Rf= 0.75
• Sodium:As Reported
• Elemental Analysis:Calculated: %C: 37.33, %H: 3.86, %N: 13.39
• Atmosphere:Inert Gas
• Water Content (Karl Fischer):As Reported
• Specific Rotation (c=0.1, Water):As Reported
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C for 6 months after receipt. Hygroscopic. Store under inert atmosphere.