85-1696-86　PF-3644022 10mg　CAS No:1276121-88-0　019315

特徴

• PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
• Synonyms:(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
• Molecular Formula:C₂₁H₁₈N₄OS
• Molecular Weight:374.46
• Purity (HPLC):≥98%
• Appearance:White to yellow solid
• Melting Point:>180°C (dec.) (lit)
• Solubility:DMSO to 40nM
• Method for Determining Identity:Proton NMR Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:Rf=0.41 (5% 7M methanolic ammonia/DCM)
• Elemental Analysis:Calculated: %C: 66.56, %H: 4.92, %N: 14.78
• Storage and Stability:Long-term storage is recommended at 4°C. Stable for 6 months after receipt.