Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Melting Point:199-203ºC
Solubility:DMSO
Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:SiO2: Dichloromethane: Methanol = 9.5: 0.5; Visualized with UV and AMCS; SIngle spot, Rf=0.6
Atmosphere: Inert gas
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
