Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor.
Synonyms:Pimaricin; Antibiotic A 5283; Tennecetin; Cl-12625; Mycophyt; Myprozine; Natacyn; Synogil
Molecular Formula:C₃₃H₄₇NO₁₃
Molecular Weight:665.73
Apperance:Pale lemon solid
Melting Point:>200°C (dec)
Solubility:Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:Amber Vial, Light Sensitive, Under Inert Atmosphere
May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
