85-1677-63　Methicillin Sodium, USP 250mg　CAS No:132-92-3　016110

特徴

• Methicillin sodium is a narrow spectrum β-lactam antibiotic related to Penicillin. β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Methicillin is mostly resistant to β-lactamases. Methicillin targets primarily the cell wall of Gram positive organisms especially Staphylococcus aureus.
• Water (Karl Fisher):≤10%
• Melting Point:196197°C
• Optical Rotation:+225°
• Solubility:Water: ~0.3mg/mlAcetone: 0.35mg/mlEthanol: 40mg/ml
• MIC:Staphylococcus aureus: 0.5ug/ml-32ug/ml
• Storage:-20°C