85-1620-77　CHIR-99021 Hydrochloride 10mg　CAS No:1797989-42-4　006005

特徴

• CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
• Synonyms:6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride
• Molecular Formula:C22H19Cl3N8
• Molecular Weight:501.80
• Appearance:Supplied as a pale beige solid
• Purity:~90%
• Atmoshpere:Inert gas
• Melting Point:>238°C (dec)
• Solubility:DMSO (slightly), Methanol (slightly)
• Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:SiO2; Dichloromethane : Methanol : Ammonium Hydroxide = 9 : 1 : 0.1; Visualized with UV and AMCS; Single spot, Rf=0.40.
• Chloride Content:As reported
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.
• Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.