85-1606-68　［受注停止］Benzo[a]pyrene Diol Epoxide (BPDE) 2.5mg　CAS No:58917-67-2　003780

特徴

• Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis.
• Synonyms:(7R,8S,8aS,9aR)-rel-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; (7α,8β,8aα,9aα)-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; (±)-7α,8β-Dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (±)-7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (±)-anti-BPDE; anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; trans-7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
• Molecular Weight:302.32
• Molecular Formula:C₂₀H₁₄O₃
• Purity:~95%
• Appearance:Pale yellow to yellow solid
• Melting Point:164-166°C
• Solubility:DMSO (Slightly)
• Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:C18: Isopropanol: ammonium = 9.5:0.5. Visualized with UV and AMCS; Single spot, Rf=0.65
• Storage and Stability:Powder is stable for 6 months after receipt at 4°C. Hygroscopic. Under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.