ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice. Furthermore, ZSTK474 did not show significant toxicity at the doses tested.
Solubility:Soluble in DMSO at 20mg/ml; soluble in ethanol at 2.5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
