Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis." Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1." FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A., et al. "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli." Oncogene 15: 2321-2331 (1997).
Solubility:Soluble in DMSO at 100mg/ml; soluble in ethanol at 12.5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
