85-1562-59　MEK1, 2 Inhibitor (U0126) 25mg　CAS No:109511-58-2　M2865-50A

特徴

• Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. In aqueous and certain organic solvents M2865-50A exists as an equilibrium mixture of 2 isomers which cannot be permanently separated. The 2 individual isomers have equivalent biological activity because they give rise to the same equilibrium mixture of isomes in aqueous solutions.
• Synonyms:MEK1, 2 Inhibitor,; Bis[amino[(2-aminophenyl)thio]methylene]Butanedinitrile); 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene
• Molecular Formula:C18H16N6S2
• Molecular Weight:380.49
• Appearance:Supplied as a white powder.
• Purity:≥99% (HPLC, TLC)
• Solubility:Soluble in DMSO at 200mg/ml. Very poorly soluble in ethanol and water. Maximum solubility in plain water is estimated to be about 10-50uM.
• Melting Point:130-132.5ºC
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.