85-1562-45　Irinotecan, Hydrochloride Salt, Trihydrate 5g　I8611-02

特徴

• Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death.
• Synonyms:[1,4'-Bipiperidine]-1'-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester Hydrochloride Trihydrate; Campto; CPT11; Irinotecan hydrochloride trihydrate
• Molecular Formula:C₃₃H₄₅ClN₄O₉
• Molecular Weight:677.18
• Appearance:White to off-white solid
• Purity (HPLC):≥99%
• Purity (TLC):≥99%
• Melting Point:>245°C (dec.)
• Solubility:Methanol (Sparingly); Soluble in DMSO at 100mg/ml; very poorly soluble in ethanol; soluble in water at 25mg/ml; buffers, serum, or other additives may increase or decrease the aqueous solubility.
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.