85-1562-38　GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine) 100mg　G9951-25

特徴

• GW2580 is a small-molecule inhibitor of cFMS kinase; at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1uM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro.
• Melting Point:209-210.5°C
• Elemental Analysis:CalculatedC = 65.56%H = 6.05%N = 15.29%
• FoundC = ~65%H = ~6%N = ~15%
• Solubility:Soluble in DMSO at 40mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
• Storage and Stability:Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.