85-1562-21　［受注停止］FK-506 (Fujimycin, Tacrolimus) 50mg　CAS No:104987-11-3　F4522-01

特徴

• FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction.
• Synonyms:Advagraf; FR 900506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide
• Molecular Formula:C44H69NO12
• Molecular Weight:804.02
• Appearance:Supplied as an off-white to white powder
• Purity:≥99% (HPLC, TLC)
• Elemental Analysis:Calculated:C: 64.43%H: 8.70%N: 1.71%
• Solubility:Soluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.