85-1562-20　Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride) 50mg　CAS No:162359-56-0　F4513-40

特徴

• Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis.
• Solubility:Soluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water. Up to 25ul of a solution of 13.8mg/ml (40mM) F4513-40 in 100% DMSO can be diluted into 5ml of plain water without precipitation, giving a final concentration of 200uM. In contrast, even a 1:1000 dilution of the same 13.8mg/ml DMSO stock solution into 10mM PBS, pH 7 results in a precipitate. Thus, F4513-40 solubility in PBS is likely to be well below 100uM, perhaps as low as 1-10ug/ml. Either DMSO, ethanol or plain water should be used as the solvent until the final dilution is made into culture medium
• Elemental Analysis:Calculated:C=66.35%H=9.96%Cl=10.31%N=4.07%
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.