Bexarotene (LGD-1069) is a synthetic retinoid analog with specific affinity for the retinoid X receptor and belongs to a group of compounds called rexinoids. It is an oral, noncytotoxic drug that was approved in Europe and in the U.S.A. for the treatment of refractory advanced-stage cutaneous T-cell lymphomas (CTCL).
Synonyms:4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid; LG 100069; LG 1069; LG 69; LGD 1069; RO 26-4455; SR 11247; Targret; Targretin; Targretyn; Targrexin
Molecular Formula:C24H28O2
Molecular Weight:348.48
Appearance:White to off-white solid
Purity:≥99%
Melting Point:230-231°C
Solubility:DMSO (50mg/ml, clear, colorless solution); Soluble in ethanol at 10mg/ml with warming; very poorly soluble in water. Maximum solubility in plain water is estimated to be about 10-50uM.
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
