Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. This intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. Connexins are a family of integral membrane proteins that oligomerize to form intercellular channels that are clustered at gap junctions. Connexins share a common transmembrane (TM) topology. Each connexin is thought to contain 4 TM domains, with two extracellular and three cytoplasmic regions.
Connexin-mimetic peptides, i.e. peptides that are identical with a short aa sequence on the Cx subunit have recently emerged as tools to block Connexin hemi-channels (CxHcs) with little or no immediate effects on gap junctions. Gap 26 corresponds to aa sequence on the first extracellular loop of Cx43. The sequence comprises conserved domain VCYD which interfaces with the membrane. Gap26 inhibits CxHc within minutes and gap junction later. Peptides homologous to first Extracellular loop motifs of Connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：1mg
Source Antigen：Synthetic peptide
Grade：Purified
Purity：~90% (HPLC)
Form：Supplied as a lyophilized powder. Reconstitute with DMF.
