Hepatitis resulting from infection with viruses other than Hepatitis A Virus (HAV) and Hepatitis B (HBV) virus was previously referred to as non-A, non-B hepatitis. The first characterized non-A, non-B hepatitis agent was that responsible for parentally transmitted non-A, non-B hepatitis, or what is now called Hepatitis C Virus. This was followed by the cloning of a portion of the fecal-orally-transmitted agent, the Hepatitis E Virus (HEV)
Hepatitis E Virus has been referred to as enterically transmitted non-A, non-B hepatitis. Epidemics of enterically transmitted Hepatitis E Virus have been recognized worldwide but occur principally in developing countries. They have been reported in Southeast Asia, central Asia, Africa, Mexico, and Central America. In these areas, contaminated water has been implicated as the principal vehicle of virus transmission. Although HEV and HAV are transmitted in a similar manner, there are major differences in the clinical, pathological, and epidemiological courses of these two viruses. In particular, the mortality rate for HEV infection is 1 to 2%, or approximately 10-fold greater than that seen for HAV. Infection with HEV is particularly fatal for pregnant women, for whom the mortality rate can be as high as 10 to 20%.
Kit Components:1. H1927-04A: Microtiter Plate, 1x96 wells. Pre-coated with mixture of synthetic HEV polypeptides
2. H1927-04B: Pab (HRP), 1x12ml. Horseradish peroxidase conjugated goat anti-human IgM antibody. Ready to use
3. H1927-04C: Non-Reactive Control, 1x1ml. Inactivated normal human serum diluted in Sample Diluent, to be used without dilution
4. H1927-04D: Reactive Control, 1x1ml
Inactivated human serum, to be used without dilution
5. H1927-04E: Sample Diluent, 1x60ml
Buffered solution with animal serum and preservative
6. H1927-04F: Wash Buffer, 20X, 1x60ml
20-fold concentrated solution of buffered surfactant
Storage and Stability:Store all components at 4°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
