85-1553-55　［受注停止］LBH-589 (Panobinostat, NVP-LBH589) 10mg　CAS No:404950-80-7　L1535

特徴

• Panobinostat, a histone deacetylase inhibitor, is being tested in humans against cutaneous T cell lymphoma, prostate cancer, myelodysplastic syndromes, breast cancer, chronic myelogenous leukemia, and other types of malignant disease. Panobinostat inhibited histone deacetylase and induced acetylation of histone H3 and alpha-tubulin protein in human umbilical vein endothelial cells (HUVEC), which resulted in induction of G(2)-M cell cycle arrest and inhibition of HUVEC proliferation and viability. Panobinostat at noncytotoxic concentrations inhibited endothelial tube formation, Matrigel invasion, AKT activity, extracellular signal-regulated kinase 1/2 phosphorylation and chemokine receptor CXCR4 expression. It aslo reduced angiogenesis and PC-3 tumor growth in mice.
• Synonyms:(2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide; LBH 589; LBH-589
• Molecular Formula:C₂₁H₂₃N₃O₂
• Molecular Weight:349.43
• Appearance:Supplied as a white to off-white powder.
• Purity:≥99%
• Solubility:Soluble in DMSO at 200mg/ml; soluble in ethanol at 5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50uM; buffers, serum or other additives may increase or decrease the aqueous solubility.
• Elemental Anaylsis:Calculated:C=72.18%H=6.63%N=12.03%
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.