MTAP (Methylthioadenosine phosphorylase) is important in polyamine metabolism and for the salvage of both adenine and methionine. It is involved in the metabolism of MeSAdo (methylthioadenosine), a by-product of the synthesis of the polyamines spermidine and spermine. MTAP is deficient in many cancers because the MTAP gene is co-deleted with the tumor suppressor p16.
Source:Recombinant human MTAP, aa2-end, with N-terminal GST tag, expressed in E. coli.
Applications:Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
仕様
Size：50ug
Source Antigen：Recombinant human MTAP, aa2-end, with N-terminal GST tag, expressed in E. coli.
Grade：Purified
Purity：≥80%
Form：Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potiassium chloride, 18mM glutathione, 3mM DTT, 10% glycerol.
