Renin is a aspartyl protease that plays a crucial role in the regulation of blood pressure and salt balance through the rennin-angiotensin system. It cleaves angiotensinogen to generate angiotensin I, which can be fur ther converted by angiotensin converting enzyme (ACE) to angiotensin II . Angiotensin II is the active molecule of the rennin-angiotensin system that acts by binding to angiotensin receptors type 1 and 2 (AT-1 and AT-2), and has direct pathophysiological effects on the heart and peripheral vasculature. After secretion, inactive prorenin can be proteolytically activated by trypsin, cathepsin B, or other proteinases. Because of its unique specificity, i nhibition of Renin is widely studied to provide selective therapy for hypertension, congestive heart failure and associated disorders.
Source:Murine myeloma cell line, NS0derived Leu22-Arg402, with a C-terminal 10-His tag
SDS-PAGE: 45-55kD, reducing conditions.
Biological Activity:The specific activity is ≥35pmoles/min/ug.
Endotoxin: ≤1EU/ug (LAL)
Storage and Stability:For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：20ug
Source Antigen：Recombinant, Murine myeloma cell line
Grade：Highly Purified
Purity：≥95% (SDSPAGE)
Form：Supplied as a liquid in MES, sodium chloride.
