CD39L1, also known as ENTPD2 and NTPDase2, is an ecto-nucleotidase belonging to the CD39 family. It is found on the surface of vascular adventitial cells and accessory vascular cells. CD39L1 is a Ca2+- and Mg2+-dependent enzyme that activates platelets by preferentially converting ATP to ADP. CD39L1 plays a role in regulating thrombosis and inflammation. It is considered to be a therapeutic target for thromboregulation and the treatment of vascular inflammation.
Source:Chinese Hamster Ovary cell line, Cho-derived Cys 26-Ser462, with a C-terminal 6-His tag
SDS-PAGE: 60-80kD, reducing conditions.
Biological Activity:Measured by its ability of to hydrolyze the 5’-phosphate groups from the substrate adenosine-5’-triphosphate (ATP). The specific activity is ≥9,000pmoles/min/ug.
Endotoxin: ≤1EU/ug (LAL)
Storage and Stability:For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
