Interleukin 4 induced protein 1(IL4I1), also known as protein FIG1 and L amino acid oxidase, is encoded by a B cell IL4 inducible gene, FIG1, and is highly expressed in primary metastinal B cell lymphomas (14). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1 has L amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hI L4I1 inhibited the proliferation of CD3 stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5) . Its inhibitory effect was dependent on enzymatic activity and H2O2 production. Its restricted expression to l ymphoid tissues indicates that it may play an important function in the immune system (1, 4).
Chinese Hamster Ovary cell line, CHO-derived Gln22 Ser567, with a C-terminal 6 His tag,. Swiss/UniProt Accession: Q96RQ9
Structure:Monomer
Molecular Weight:61kD, SDS-PAGE: 70-75kD
Activity:Measured by its ability to oxidize phenylalanine in a horseradish peroxidase coupled assay. The specific activity is ≥150pmol/min/ug, as measured under the described conditions.
Storage and Stability:Store at -70°C. Aliquot to avoid repeated freezing and thawing. Stable for 6 months after receipt at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ug
Source Antigen：Recombinant, CHO cells
Grade：Highly Purified
Purity：≥95% by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤0.1EU/ug (LAL)
Form：Supplied as a liquid in 20mM Tris, pH 7.5, 120mM sodium chloride, 20% glycerol.
