85-1540-59　Retinoic Acid (all-trans Retinoic Acid, Vitamin A Acid, ATRA, Tretinoin) 25g　CAS No:302-79-4　R1690-01E

特徴

• Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation. Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
• Synonyms:(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; Tretinoin; all-trans-Retinoic acid, ATRA; Vitamin A acid; 15-Apo-beta-caroten-15-oic acid; Aberel; Avita; Retin-A; Retinova; Isotretinoin EP Impurity A
• Molecular Formula:C₂₀H₂₈O₂
• Molecular Weight:300.44
• Appearance:Yellow to light orange lyophilized powder.
• Purity:98-102% (HPLC)
• Solubility:Chloroform, DMSO, Methanol (Sparingly)
• Loss on Drying:≤0.5%
• Melting Point:168-170˚C
• Sulfated Ash:≤0.1%
• Heavy Metals:≤0.002%
• Limit of Isotretinoin:≤5%
• Storage and Stability:Powder may be stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light and temperature sensitive. Keep under inert atmosphere