Diamine oxidase (DAO) is a flavoprotein/enzyme which catalyzes the aerobic oxidation of amines to the corresponding aldehyde and ammonia. Diamine oxidase is synthesized primarily in the gastrointestinal mucosal cells. Serum levels of DAO have been used as an indicator of the integrity and/or functional mass of the intestinal mucosa. The enzyme is also produced by the placenta and is elevated in newborn serum.