Virginiamycin S1 is a main component of virginiamycin preparations.
Virginiamycin S1 is one of a family of depsipeptide antibiotic co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin S1 also known as Staphylomycin S and Factor S, among other synonyms were discovered independently and named by several groups leading to considerable confusion in the literature. Virginiamycin S1 acts a synergist binding to the conformational change induced by ostreogrycin A of the peptidyl transferase centre of the 50S ribosome. Virginiamycin S1 differs from virginiamycin B in lacking the dimethylamino moiety on the phenyl ring.
Synonyms:Staphylomycin S, PA 114B2, Antibiotic 899, Antibiotic PA 114B2, Antibiotic 1745Z3B, Factor S
Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
