A polycyclic polyether, isolated from marine dinoflagellate Karenia breve (Ptychodiscus brevis or Gymnodinium breve in earlier literature) is one of the toxins responsible for the ‘red tide’ massive fish kills. This compound forms a ladder-like-arranged multiple ring structure with an unusual acrolein side-chain on one of the terminal rings. Together with other congeners, they are known to disrupt neurotransmission by opening sodium channels.
Brevetoxin B is a neurotoxin produced by algae called Ptychodiscus brevis Davis or Gymnodinium breve Davis. The algae proliferate during red tide incidents, vast phytoplankton blooms that actually turn the sea red, brown, or green. For example, 14 humpback whales died and many people were sickened by a red tide incident in 1987 in Cape Cod Bay, Mass. Brevetoxin B exerts its neurotoxic effects by binding to sodium channels on nerve and muscle cell membranes, causing an excessive influx of sodium ions across the membranes, which leads to cell death.
Solubility:Acetone, ethyl acetate, 100% methanol, 100% ethanol. Can be subsequently diluted into aqueous solutions for biological studies.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile buffer. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
This product does not contain any animal derived additives, such as albumin. Harmonized Tariff Code: 2392.29.5050
仕様
Size：100ug
Source Antigen：Karenia brevis
Grade：Highly Purified
Purity：≥ 95% by HPLC
Form：Supplied as a white to off white crystalline solid.
