Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol has also been demonstrated to cause a dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
Purity: >95% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO
