Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. It displays a selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin are currently in several clinical trials for cancer therapy.
Purity: >99% by HPLC
Solubility: Soluble in THF or DMSO. Poorly soluble in methanol and water.
Related to: Staurosporine, Antibiotic UCN-01, Antibiotic UCN-02
