Fostriecin is the most fully characterized member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A. Related to Sultriecin.
Solubility:Soluble in water; optimal stability in aqueous buffered solutions at pH 6.5. Note: Hydrolysis of the phosphate ester will result from inappropriate storage. Use only freshly prepared solutions.
Storage and Stability:Store lyophilized powder at -20°C. Caution: Hygroscopic; keep cool and dry. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
