Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.
Purity: >95% by HPLC
Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.
Related to: Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin A
