Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Dinactin has not previously been available for intensive investigation.
Molecular Formula:C₄₂H₆₈O₁₂
Molecular Weight:764.98
Purity:≥95% (HPLC)
Appearance:Colorless film
Solubility:Soluble in ethyl acetate or DMSO, moderately in soluble ethanol or methanol
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
