O-deacetyl-ravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light dependent antitumour activity. Microbial Screening Technologies in-house bioassays detected weak antibacterial and antifungal activity. O-Deacetyl-ravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor.
Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, Gilvocarcin V
