Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.
Purity: >98% by HPLC
Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Related to: Chrysomycin A, Gilvocarcin M, Gilvocarcin V, O-Deacetyl-ravidomycin
