85-1533-23　5-Trifluorothymidine 100mg　CAS No:70-00-8　T8416-72

特徴

• Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.
• Synonyms:Trifluridine; Trifluorothymine Deoxyriboside; α,α,α-Trifluorothymidine; 2’-Deoxy-5-(trifluoromethyl)uridine; 5-(Trifluoromethyl)-2’-deoxyuridine; Viroptic
• Molecular Formula:C₁₀H₁₁F₃N₂O₅
• Molecular Weight:296.20
• Appearance:White crystalline powder
• Purity:≥99.5% (HPLC)
• Infrared Spectrum:Conforms to structure
• Loss on Drying:≤1%
• 5-(Trifluoromethyl)uracil:≤1%
• UV Max:260nm
• Optical Rotation:
[a]D20 = + 49 ± 2º (C=0.3% in H2O)
• Melting Point:186-189°C
• Solubility:Methanol (Slightly), DMSO (>25 mg/ml), H₂O (>10mg/ml)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.