TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.
Method for Determining Identity:Proton NMR Spectroscopic Analysis and Mass Spectrometric Analysis
TLC Conditions:SiO2; Dichloromethane: Methanol: Acetic Acid; 9.5ml: 0.5ml: 10drops; Visualized with UV and AMCS; Single spot Rf=0.65.
Appearance:Supplied as a white solid.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
