85-1529-91　Temozolomide 25mg　CAS No:85622-93-1　T2510-45

特徴

• Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.
• Molecular Formula:C₆H₆N₆O₂
• Solubility:Dichloromethane, DMSO, Methanol
• Primary Target:DNA guanine residues
• Molar Mass:194.2
• Melting Point:>177°C (dec.)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：25mg
• Source Antigen：Synthetic
• Grade：Highly Purified
• Form：White to Off-White Solid
• Molecular Formula：C₆H₆N₆O₂
• Molecular Weight Non Ab：194.2
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：85622-93-1

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