A selective alpha-1A adrenoceptor antagonist that has preferential selectivity for the alpha-1A adrenoceptor in the prostate versus the alpha-1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for alpha-1A, alpha-1B and alpha-1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo.
Melting Point:231-233ºC
Solubility:Methanol
Method for Determining Identity:Proton NMR (CD3OD) Spectroscopic and Mass Spectrometric analysis
TLC Conditions:SiO2; Dichloromethane: Methanol=4:1; Visualized with UV and AMCS; Rf=0.55
Specific Rotation:-3.0º (c=0.35. Methanol)
Chloride Content:8%
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
