A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells.
Appearance:Supplied as a white to off-white solid
Purity:~90% (HPLC, TLC)
Melting Point:156-158°C
Solubility:DMSO, Ethanol
TLC Conditions:SiO2; Chloroform: Methanol: Water: Acetic Acid; 75: 25: 2: 2; Visualized with UV and by exposure to iodine vapor.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.