85-1528-22　Simvastatin-d6 1mg　S1013-85H

特徴

• Deuterated Simvastatin, a competitive inhibitor of HMG-CoA reductase. A deuterated synthetic analog of lovastatin. Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
• Synonyms:2,2-(Dimethyl-d6)butanoic Acid(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; (+)-Simvastatin-d6; Cholestat-d6; Lipex-d6; Novo-Simvastatin-d6; Simvotin-d6; Sinvacor-d6; Statin-d6; Zocor-d6; Zorced-d6
• Molecular Formula:C₂₅H₃₂D₆O₅
• Molecular Weight:424.6
• Appearance:White to off-white solid
• Purity:≥95%
• Solubility:Chloroform (Slightly), Methanol (Slightly)
• Melting Point:117-121˚C
• Method for Determining Identity:1H NMR (CDCL3) and Mass Spectrometric Analysis
• TLC Conditons:SiO2; Dichloromethane: Methanol: = 9: 1; Visualized with UV and KMnO4; Single Spot, Rf=0.60
• Normalized Intensity:d0=0.10%, d1=0.00%, d2=0.01%, d3=0.00%, d4 =0.17%, d5=0.27%, d6=99.46%
• Elemental Analysis:Calculated: %C:70.72, %H:9.02
• Specific Rotation (c=0.1, methanol):As reported
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. Hygroscopic, Under Inert Atmosphere.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.