(S)-Pramipexole enantiomer. A dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.
Molecular Formula:C10H17N3S
Melting Point:125-127°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Method for Determining Identity:1H NMR Spectroscopic and Mass spectrometric analysis
TLC Conditions:SiO2; dichloromethane: NH4OH; 6: 1:3dropsVisualized with UV and AMCS; Rf= 0.55
Specific Rotation: -63º.
Appearance:White to Off-White Solid
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
