A blue fluorescent derivative of cGMP is a useful substrate the assay of cyclic nucleotide phosphdiesterase. Also inhibits calmodulin-dependent activation of cyclic nucleotide phosphodiesterase by peptide segments of HIV envelope glycoproteins has been monitored using MANT-cGMP.Fluorescence: max. Abs. 359nm; max. Em. 448nm; e x 10-3: 5.2.
Appearance:Supplied as a pale yellow solid.
Purity:~90%
Melting Point:>230°C (dec.)
Solubility:Methanol (Slightly), Water (Slightly)
Atmosphere:Inert Gas
Sodium Content:As Reported
Method for Determining Identity:Proton NMR (D2O) and Mass Spectrometric Analysis
Specific Rotation:-12.3ºC (c=0.2, Methanol)
TLC Conditions:As Reported
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
