An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.
Source:Synthetic
Purity:~90%
Form:Supplied as an off-white crystalline solid
Melting Point:159-161°C
Solubility:Chloroform, Methanol
Method for Determining Identity:Proton NMR and Mass Spectroscopic Analysis.
TLC Conditions:SiO2: Hexane: Ethyl Acetate; 3:2; Visualized with UV and KMnO4; Single spot; Rf=0.6.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.