85-1486-49　Cyclosporin D, Val2 (Val2-cyclosporine (Val2)DH-CS) 10mg　CAS No:63775-96-2　C8901

特徴

• The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process.
• Synonyms:Val2-cyclosporine, Cyclosporin D, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl
• Molecular Formula:C63H113N11O12
• Molecular Weight:1216.64
• Appearance:White solid
• Purity:≥95%
• Melting Point:>136°C (dec.)
• Solubility:Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.