85-1484-89　Clavulanic Acid, Potassium Salt (MM 14151, Potassium Clavulanate) 50mg　CAS No:61177-45-5　C5836

特徴

• Clavulanic acid is a beta-lactam antibiotic produced by several species of the genus Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic but is a potent inhibitor of beta- lactamases. In combination with penicillin and cephalosporins it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the beta-lactamase.
• Synonyms:Timentin; Ticarcillin; MM 14151; [2R-(2α,3Z,5α)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptane-2-carboxylate potassium salt
• Molecular Formula:C8H8KNO5
• Molecular Weight:237.25
• Appearance:Brownish orange solid
• Purity:≥95%
• Melting Point:>170.5°C (dec)
• Solubility:Water (Hot, Sparingly)
• Atmosphere:Inert Gas
• Method for Determining Identity:Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:C18; Acetonitrile: Water= 9:5; Visualized with UV and Ninhydrin; single spot, Rf= 0.55
• Potassium:~16% by Ion chromatography
• Elemental Analysis:Calculated: %C: 40.50, %H: 3.40, %N: 5.90
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under Inert atmosphere.